| Senator | State | Re-election |
|---|---|---|
| Tammy Baldwin | Wisconsin | 2018 |
| Richard Blumenthal | Connecticut | 2022 |
| Cory Booker | New Jersey | 2020 |
| Al Franken | Minnesota | 2020 |
| Kirsten Gillibrand | New York | 2018 |
| Kamala Harris | California | 2022 |
| Martin Heinrich | New Mexico | 2018 |
| Mazie K. Hirono | Hawaii | 2018 |
| Patrick J. Leahy | Vermont | 2022 |
| Edward J. Markey | Massachusetts | 2020 |
| Jeff Merkley | Oregon | 2020 |
| Brian Schatz | Hawaii | 2022 |
| Jeanne Shaheen | New Hampshire | 2020 |
| Tom Udall | New Mexico | 2020 |
| Elizabeth Warren | Massachusetts | 2018 |
| Sheldon Whitehouse | Rhode Island | 2018 |